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Resources

Case studies, publications, and dashboard how-tos from trials we have run.

Spotlight

What happens before the sample hits the cytometer

Fresh-X compared fresh, cryopreserved, and TokuKit-fixed whole blood across the same draws. Fixation held populations that freezing lost.

Proof from trials

All case studies

Case study

Leading cell therapy developer scales 25 marker spectral flow panel to 280+ samples in multi-cohort trial

Longitudinal spectral flow cytometry profiling of 280+ samples to support a complex Phase I/II dose escalation trial.

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Case study

AML drug developer selects Teiko for 500+ specimen trial

The goal is to assess dose-dependent drug effects on AML blasts and immune cells using TokuKit fixation. Teiko’s 43-marker CyTOF panel processes ~500 samples. Results track 700+ subsets. The developer cut specimens from 3 to 1, saving ~$200 each, capturing responses within 30 minutes. Runtime is ongoing.

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Case study

Public immunotherapy developer uses 40+ parameter cytometry to uncover immune cells driving response in ~200 blood samples in Phase 1 study

A $5B+ immunotherapy company aimed to assess drug impact on immune cell composition in 20 healthy volunteers across two doses and placebo in Phase 1. Teiko’s 42-marker panel analyzed 200 PBMC samples over 6.5 weeks. Results confirmed myeloid subset changes and significant T cell shifts, increasing resolution 17X to 858 subsets for indication selection.

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Published work

All publications

Publication

Programmable Panels: A Web-Based Design Studio to Accelerate Custom Cytometry Panel Development for Clinical Immune Profiling

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Publication

Unsupervised clustering identifies a CD161⁺ MAIT-like T cell population associated with anti–PD-1 response and immune-related toxicity in stage II-IV melanoma

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Publication

Teiko-powered spectral flow reveals dose-dependent immune dynamics in Obsidian's TIL trial

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Teiko Studies

STUDY

Cyto-Chex yields decreased B cell frequencies and increased double-positive T cell frequencies after 7 days. Transfix sees a loss of T-bet expression.

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STUDY

From 0.5 mL to 3 mL blood inputs, TokuKit preserves immune cell populations within +/-2% of the standard 2 mL blood volume.

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STUDY

Blood should be transferred from TokuKit's Buffer One to Buffer Two within 15 minutes to preserve population frequencies.

See the results

Use the dashboard

How-to

How to use Top Statistical Results to identify the most significant immune shifts

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How-to

How to share your Teiko dashboard view with colleagues

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How-to

How to review the gating plots for each sample in Sample QC

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Browse by collection

Articles→FAQ→Videos→Publications→Case studies→Cytometry guides→Dashboard how-tos→Data specifications→Planning tools→

Plan the next draw

All planning tools

Planning tool

Blood Specimen Volume Calculator

The planner helps to determinine the right blood sample volume to reliably measure key immune cell populations, especially rare ones.

Planning tool

Assay Precision Calculator

Set parameters like the effect size of your drug, estimated cost, the number of patients, and more to estimate the cost of your clinical trial.