For your clinical trial, Teiko builds a custom panel from our 33- or 41-marker mass cytometry backbone, performs bead calibration, generates standard curves, and delivers results your team can act on.
You choose the markers, our scientists take it from there.
Each calibration bead carries a known number of antibody-binding sites. By measuring the signal intensity of all five bead populations, we build a curve that maps raw signal to a quantified number of molecules per cell.
A dedicated antigen density tab reports target molecules per cell for every profiled immune population. Display results by endpoint or group, and filter by cohort, cell type, endpoint, and group.
Explore the dashboard →
Antigen density supports many translational questions. Here are three ways teams put it to work.
Relative cell frequencies can mask why some patients respond and others don't. Density sets precise baseline target thresholds to screen in the right patients.
Immune cells can lose the antigen your drug targets, and resistance follows. Antigen density shows when it drops below the level your drug needs to work, so teams can adjust the combination or timing.
Before dosing patients, antigen density help define how much of your target population is on different cell populations. This analysis can help you define a safety window.
Relative signal intensity depends on the metal a marker is conjugated to, so two targets can read as comparable when their true expression differs widely. Antigen density normalizes every marker to the number of molecules per cell, giving an apples-to-apples comparison across your panel. For the full background, read our explainer: What is antigen density anyway? →
We run a series of calibration beads with a known number of antibody-binding sites, measure the signal of each, and fit a standard curve. Each marker's signal on your samples is mapped onto that curve and reported as antibodies bound per cell.
Antigen density is quantified by mass cytometry, with your custom panel built on our 33- or 41-marker backbone. Running quantification within a deep immune panel means you get density in the context of the full immune landscape, not as a standalone readout.
You can add 1–10 custom markers to your panel. To see the standard markers and how customization works, explore our custom mass cytometry panels →
Antigen density panels run on both cryopreserved PBMCs and whole blood. Whole blood can be processed directly from TokuKit-fixed samples, so clinical sites fix at the time of collection without central-lab PBMC isolation.
Share the markers and sample type you're working with, and our scientists will help design the right custom panel with you.
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