Start with a focused panel. Expand when you are ready.
Focused TBNKM, then the full tree on the same sample.
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$900 unlock. Same sample.
Every sample is processed on a 25- or 41-marker panel. Unlock T, B, NK, and monocytes first. Unlock the rest later. One sample.
Talk to usEvery sample is processed on the full panel first.
$1,000 per sample.
$900 per sample, about two weeks.
Focused TBNKM, then the full tree on the same sample.
$900 unlock. Same sample.
Scenario: first-in-human. 3 of 10 patients respond.
Day 0: 10-marker TBNK on fresh blood.
Day 0: TokuKit. Full 41-marker. TBNKM at $1,000.
Week 4: 3 responders. TBNK does not explain why.
Week 4: same 3 responders. Full tree already archived.
Week 6: still no mechanism.
Week 6: unlock the rest.
Then: recollect. Months of wait. Double the cost.
Then: data in two weeks. $900 per specimen. Same sample.
per specimen
Gated TBNKM, dashboard, QC. Unlock remaining populations within 6 months.
upgrade per specimen
Full populations, FCS and GatingML, two consulting hours, premier clustering option.
Something we're thinking about, but not with this release. Here are the markers included in our basic TBNK panels:
| Spectral | Mass Cytometry | |||||
|---|---|---|---|---|---|---|
| PBMC (Viability, FSC x SSC) |
Marker | Whole Blood (fixed) |
PBMC (viability) |
Marker | Whole Blood (fixed) |
|
| CD4 | CD4 T cell | CD4 | CD4 | CD4 T cell | CD4 | |
| CD8 | CD8 T cell | CD8 | CD8 | CD8 T cell | CD8 | |
| CD45 | Leukocyte | CD45 | CD45 | Leukocyte | CD45 | |
| Neutrophil Cleanup | CD66b | CD66b | Neutrophil Cleanup | CD66b | ||
| CD3 | T cell | CD3 | CD3 | T cell | CD3 | |
| CD19 | B cell | CD19 | CD19 | B cell | CD19 | |
| CD56 | NK Cell | CD56 | CD56 | NK Cell | CD56 | |
| CD16 | NK, Monocyte | CD16 | CD16 | NK, Monocyte | CD16 | |
| CD14 | Monocyte | CD14 | CD14 | Monocyte | CD14 | |
| CD11c | Conventional DC | CD11c | CD11c | Conventional DC | CD11c | |
Unsupervised analysis isn't included in the focused 10-marker panel, but it's available whenever you're ready to dive deeper. Once you upgrade to the full panel, unsupervised analysis is included to help you explore the full complexity of your data.
Upgrades are generally done in full batches, but we’re open to discussing alternative approaches if your study requires more flexibility. Contact our team to explore what might work best for you.
Yes. The dashboard will display the full gating tree, but any locked populations will appear greyed out until you upgrade.
This is handled on a case-by-case basis. TokuFocus was built for our off-the-shelf panels, but we’re open to discussing custom panel options depending on your study needs. Reach out to our team to explore what’s possible.
