Peripheral immune features associated with severe adverse events in melanoma

Poster Highlights

• Immune-related adverse events (irAEs) are major barriers to clinical management and further development of cancer immunotherapy.

• We used mass cytometry to characterize the immune system before and during presentation of severe (grade 3+ that required clinical intervention) irAEs to identify cell signatures correlated with irAE development.

• We found that patients with severe irAE have fewer immunosuppressive cells at baseline and more activated and tumor-reactive T cells during irAE presentation.

• These findings suggest severe irAEs are the result of a lower baseline state of immunosuppression.